Recent Progress of Combinatorial Chemistry.

Recent progress in theoretical and computational chemistry.

Theoretical and Computational Chemistry has seen a remarkable development in the past decades. While it started as a discipline of a few experts in the 1960s, the field has grown enormously due to advances in computational resources and software packages. In addition to the dramatic increase in computer power, a wide range of methods with predictive capabilities such as density functional theor...

Recent Progress in Allergen Immunotherapy

The efficacy of allergen immunotherapy for the treatment of allergic rhinoconjunctivitis with or without seasonal bronchial asthma and anaphylaxis caused by the sting of the hymenoptera class of insects has been clearly demonstrated in numerous well-designed, placebo-controlled trials. Immunotherapy whether by subcutaneous injection of allergen extract or by oral/sublingual routes modifies peri...

Recent Progress in the Chemistry and Biochemistry of Rifamycins

ABSTRACF The availability of a large number of natural and semisynthetic rifamycins made it possible to derive a clear relationship between structural features and activity against the target enzyme, the bacterial DNA-directed RNA polymerase (DDRP). Recent data are reported on the conformation of the active molecule in solution and on the Hansch approach for quantitative correlation between the...

Combinatorial chemistry

Combinatorial chemistry, which did not even exist fifteen years ago, is a new subfield of chemistry that is starting to provide insights into molecular interactions, biochemical catalysis and drug development. Instead of finding and testing naturally existing compounds for useful activity, the basic aim of combinatorial chemistry studies is to create vast numbers of new, synthetic compounds and...

Combinatorial chemistry.